• PR-619: A Translational Lens on DUB Biology

  2026-08-22

  PR-619 provides a reversible, broad-spectrum way to interrogate cysteine-dependent deubiquitylating enzymes in cell-based research. This article connects ubiquitination pathway research with tumor immunology, autophagy, and neurodegeneration while defining practical controls, translational limits, and next-step hypotheses.

• Isoproterenol Sulfate Dihydrate in SAN Research

  2026-08-22

  Isoproterenol sulfate dihydrate, also called Isoproterenol hemisulfate, is a non-selective beta-adrenergic agonist for controlled studies of beta-adrenergic receptor signaling. Its direct stimulation of beta-1 and beta-2 receptors provides a defined pharmacological challenge for human SAN-plexus assembloid and cardiovascular research.

• VDR, GPX4, and Ferroptosis in Cisplatin AKI

  2026-08-21

  Hu et al. show that ferroptosis is a meaningful component of cisplatin-induced acute kidney injury and identify VDR-dependent maintenance of GPX4 as a protective mechanism. The work connects a nuclear receptor transcriptional program with lipid-peroxidation control, offering a mechanistic framework for evaluating ferroptosis in renal toxicology and related oxidative stress models.

• ACSL1, FSP1, and Ferroptosis in Ovarian Cancer

  2026-08-20

  The reference study identifies ACSL1 as a regulator of ferroptosis resistance in ovarian cancer, linking fatty-acid metabolism to FSP1 N-myristoylation, stability, and membrane localization. Its findings suggest that this ACSL1–FSP1 axis helps ovarian cancer spheroids withstand oxidative stress and platinum treatment, while providing a mechanistic framework for future ferroptosis research.

• Verapamil HCl: Calcium Signaling Workflows

  2026-08-20

  Verapamil HCl supports controlled studies of calcium-channel signaling, apoptosis, inflammation, and bone remodeling. This workflow-focused guide connects practical assay design with emerging TXNIP-centered osteoporosis research while emphasizing controls, dose finding, and troubleshooting.

• FITC-Concanavalin A (ConA) Conjugate Guide

  2026-08-19

  FITC-Concanavalin A (ConA) Conjugate is a fluorescent lectin reagent for visualizing α-D-glucose and α-D-mannose residues on glycoproteins and glycolipids in cell and tissue workflows. It is suited to cell surface carbohydrate detection, immunofluorescence staining, and flow cytometry, but should not be treated as a general membrane stain, antibody substitute, or reagent for non-carbohydrate targets.

• Tacrine hydrochloride hydrate: Assay Guide

  2026-08-19

  This scenario-based guide explains how Tacrine hydrochloride hydrate, SKU C6449, can support reproducible cholinesterase, cell viability, proliferation, and neuroprotection workflows. It connects concentration selection, solvent compatibility, interpretation, and vendor evaluation to practical Alzheimer’s disease research needs.

• NMDA in Excitotoxicity Research Workflows

  2026-08-18

  Use NMDA as a controlled NMDA receptor agonist to model calcium loading, oxidative stress, and neuronal injury with clearer receptor-level attribution than complex glutamatergic stimuli. This workflow connects rapid calcium influx measurement with longer-term ferroptosis and neuroprotection endpoints relevant to retinal and neurodegenerative disease models.

• Cyanine 5-dCTP: Reliable DNA Labeling

  2026-08-18

  A scenario-based guide to using Cyanine 5-dCTP (SKU B8161) for fluorescent DNA labeling, PCR-associated detection, and orthogonal readouts in cell-based research. It connects product specifications with enzymatic oligonucleotide synthesis evidence while defining practical controls, handling limits, and interpretation safeguards.

• α-Linolenic Acid: Applied Research Workflows

  2026-08-17

  Build reproducible ALA experiments for lipid flux, cardiovascular phenotypes, inflammation, and cancer models with practical dosing, solvent, and readout guidance. A carefully bounded comparison with recent arachidonic acid vaccine research shows how to translate lipid biology without treating ALA and ARA as interchangeable.

• Dlin-MC3-DMA for LNP RNA Delivery

  2026-08-17

  Dlin-MC3-DMA provides a practical ionizable cationic liposome benchmark for comparing siRNA silencing, mRNA expression, and cell-state-dependent delivery. This workflow connects formulation control with machine-learning-guided assays, including hepatic gene silencing and exploratory microglia immunomodulation.

• PDK4 Inhibitors: From Anthraquinone Hit to 8c

  2026-08-16

  The reference study describes a structure-guided campaign that converted an anthraquinone hit into allosteric pyruvate dehydrogenase kinase 4 inhibitors, identifying compound 8c with nanomolar biochemical activity. Its metabolic stability, pharmacokinetic behavior, glucose-tolerance effects, antiallergic activity, and anticancer observations support PDK4 as a therapeutic research target while also highlighting the need for further validation.

• Prmt1–Ddx17–Sh2b1 Axis in Osteoblast Differentiation

  2026-08-15

  The reference study identifies a Prmt1–Ddx17–Sh2b1 regulatory axis that links arginine methylation to alternative splicing during osteoblast differentiation. Its findings suggest that Ddx17 stability and Sh2b1 isoform selection contribute to osteogenic capacity, while also highlighting the need for orthogonal validation before therapeutic translation.

• TGF-β, Sca-1, and Mammary Cell Plasticity

  2026-08-14

  The reference study shows that TGF-β signaling can switch Sca-1 expression, alter lineage commitment, and enrich pre-neoplastic mammary epithelial cells with tumor-initiating properties. Its key contribution is the distinction between endogenous Smad2/3/4-dependent regulation and exogenous TGF-β-driven Sca-1 loss that proceeds independently of Smad2/3.

• Asunaprevir: An Orthogonal HCV Assay Strategy

  2026-08-14

  Asunaprevir (BMS-650032) can anchor a layered strategy for studying HCV RNA replication inhibition, from direct NS3 protease engagement to cellular antiviral response. This article translates an HDAC-screening study into practical assay design without conflating HCV protease biology with NUT carcinoma mechanisms.

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