• Kinetic isotope effects KIEs inform on bond

  2020-11-10

  

  Kinetic isotope effects (KIEs) inform on bond vibrational changes between the ground state (GS) and TS of a chemical reaction and remain one of the most powerful experimental techniques for interrogating TS structure. KIEs on enzyme reactions measured by the internal Dynorphin (2-17), amide, porcin

• In agreement with the evidence on the

  2020-11-10

  

  In agreement with the evidence on the Plg-binding function of tapeworm enolases, eukaryotic enolases have been shown to be multifunctional proteins, with other activities besides their role as glycolytic enzymes (Pancholi, 2001). In this respect, several flatworms have been proved to express enolase

• br Introduction Schistosomiasis one of the

  2020-11-10

  

  Introduction Schistosomiasis, one of the major parasitic diseases that affect humans in tropical and subtropical countries, is an acute and chronic condition caused by blood flukes (trematode worms) of the genus Schistosoma (World Health Organization, 2014). Schistosomiasis infects over 240 milli

• To further confirm the roles of the CYP enzymes involved

  2020-11-10

  

  To further confirm the roles of the CYP450 enzymes involved in the metabolism of Dip in rat liver microsomes, we utilized not only chemical inhibitors but also a correlation analysis and a panel of recombinant rat CYP450 enzymes to evaluate the contribution of CYP450 enzymes. The results of the corr

• The strand domain swap in

  2020-11-10

  

  The β strand domain swap in the UbV.XR dimer appears to be a unique arrangement for a Ub-based dimer. In solution, free Ub has a KD of ∼5 mM for the monomer-dimer equilibrium, and the two subunits in the dimer adopt a range of relative orientations involving residues from Ub’s β sheet (Liu et al., 2

• br Discussion The regulation of intracellular cholesterol le

  2020-11-10

  

  Discussion The regulation of intracellular cholesterol levels is a biological process of vital importance for cellular function and integrity, and involves robust transcriptional and post-transcriptional mechanisms that are sensitive to metabolic feedback control. Amongst post-transcriptional mec

• br Materials and methods br Results

  2020-11-10

  

  Materials and methods Results Discussion Regardless of obvious beneficial effects of GC on acceleration of foetal lung and cardiomyocytes maturation (Kamath-Rayne et al., 2012; Rog-Zielinska et al., 2015), the current study revealed that GC exposure during late pregnancy induces IR and alte

• In conclusion we have found that Egr can play an

  2020-11-10

  

  In conclusion, we have found that Egr1 can play an inhibitory role on DBH promoter-driven transcription. This inhibition requires a newly identified Egr1 response Licarbazepine receptor at the −227/−224 region of DBH promoter. This inhibition appears to result from Egr1 directly bound to the DBH pr

• Addressing whether impaired activation of

  2020-11-10

  

  Addressing whether impaired activation of D1 and D2 receptors regulates memory capacity is relevant for all human pathologies that lead to reduced activation of these Quinidine sale pathways, such as ageing [39], certain genetic polymorphisms [40] and neurodegenerative disorders. In this study, we h

• Consistent with our previous study Gao et

  2020-11-10

  

  Consistent with our previous study (Gao et al., 2018b; Wu et al., 2018), we found that TCB-2 disrupted both pup preference and home-cage maternal behavior. Based on the findings that 4-h pup bcl-2 family (a technique presumably increases maternal motivation) failed to attenuate the TCB-2-induced mat

• Introduction In vitro synthetic biology has

  2020-11-10

  

  Introduction In vitro synthetic biology has received considerably less attention than in vivo processes so far (Foster and Church, 2007). However, cell-free biosynthetic production is very likely to become important for many biotechnological challenges for reasons such as (energy) efficiency, syste

• br Experimental All starting materials

  2020-11-10

  

  Experimental All starting materials and reagents were purchased from Sigma-Aldrich, Merck and Loba Chemie. Thin layer chromatography (TLC) was performed on silica gel G60 F254 (Merck) plates and eluted with the mobile phase n-hexane: ethyl acetate (70:30%v/v). Melting points were recorded on auto

• An increasing body of evidence demonstrates that MXC

  2020-11-10

  

  An increasing body of evidence demonstrates that MXC can cause neurobehavioral and neuropathological alterations [7]. In the brain, there are several steroidogenic enzymes, which are responsible for neurosteroid production. Neurosteroids are subsets of steroids that rapidly change neuronal excitabil

• We had earlier reported that collagen fibers with intact nat

  2020-11-10

  

  We had earlier reported that collagen fibers with intact native banded structure were occasionally observed in the kinase-deficient, membrane-anchored DDR2 ECD (DDR2/-KD) samples; however, in our DDR1/ECD and DDR2/ECD samples, observation of native banded structure of collagen was far more infrequen

• br Materials and methods br

  2020-11-10

  

  Materials and methods Acknowledgments Introduction Proton pumps convert the energy of high-energy compounds into the 12198 of protons across biomembranes. They play two physiological roles: pH regulation and the formation of proton-motive forces in their membranes. The simplest of these pum

15838 records 767/1056 page Previous Next First page 上5页 766767768769770 下5页 Last page