• KT182 After initial validation of the ability of Ad Cre viru

  2022-04-18

  

  After initial validation of the ability of Ad5-Cre virus to express Cre recombinase protein in glial cells in vitro and in vivo, we employed this virus to induce site-specific deletion of our target GlyT1 in the thalamus, through injection of the cKO GlyT1 mice. This transgenic line was constructed

• Oxidative stress results from the disequilibrium between lev

  2022-04-18

  

  Oxidative stress results from the disequilibrium between levels of prooxidant molecules produced and the ability of a biological system to detoxify and neutralize the reactive molecules [14]. OS is a chronic, self-perpetuating state of damage to cells and increased inflammation resulting from the co

• Resolving the molecular details of glyco

  2022-04-18

  

  Resolving the molecular details of (glyco)proteome variation in different tissues and organs of the human body is critical for the understanding of human biology and disease [59]. Glycoproteomic analysis of disease-related tissues and cells has provided valuable information to identify promising tar

• In this present study the

  2022-04-18

  

  In this present study, the availability of commercial GLUT and SGLT Carmofur directed against different epitopes, enabled us to screen for members of the SGLT family and compare the expression patterns of GLUTs and SGLTs in the different regions of the rat lens. Based on these regional and subcellu

• Although in in vitro analyses GANT sensitized

  2022-04-18

  

  Although in in vitro analyses GANT61 sensitized Daoy GSK-923295 to RITA treatment, this was not fully reflected in the in vivo xenograft studies in nude mice, as the combinatorial treatment elicited a comparable reduction of tumor growth. However, the dual drug administration reduced within-group v

• It was recently reported that aged GHSR mice in addition

  2022-04-18

  

  It was recently reported that aged GHSR−/− mice, in addition to showing alterations in meal pattern microstructure, exhibit NPY and AgRP mRNA upregulation in the ARC [56]. After an overnight fast, our animals exhibited a similar pattern of upregulated NPY and AgRP mRNA expression. Given that GHSR1a

• Different responses in feed intake have

  2022-04-18

  

  Different responses in feed intake have been noticed following administration of exogenous GHRL (peripherally or centrally) depending on animal species. In mammals, injection of GHRL stimulates food intake (orexigenic effect) (reviewed in Kaiya et al., 2013b). In contrast, in domestic birds, exogeno

• The potential therapeutic actions of GHSR in the

  2022-04-18

  

  The potential therapeutic actions of GHSR in the central nervous system has been in the limelight lately. Peripheral administration of GHSR agonists have been shown to inhibit oxidative stress, apoptosis, proinflammatory cytokine production, microglia activation, mitochondrial dysfunction, and excit

• br Materials and methods br

  2022-04-18

  

  Materials and methods Results and discussion Conclusions Notes Declaration of interest statement Acknowledgment This work was supported by the National Natural Science Foundation of China (No. 21775132, 21505112), Scientific Research Foundation of Hunan Provincial Education Departm

• br Conclusion br Methods br Introduction To predict

  2022-04-18

  

  Conclusion Methods Introduction To predict such topologies, several algorithms have been developed. Quadparser (QP), developed by the Balasubramanian group have taken an approach where sequences matching G≥nN≤mG≥nN≤mG≥nN≤mG≥n model in which the lengths of G-tracts are at least n and lengths

• GLP is released in response to ingestion of nutrients

  2022-04-18

  

  GLP-1 is released in response to ingestion of nutrients including carbohydrates, protein, and fat. Recent studies aimed at identifying the receptors involved in nutrient stimulated GLP-1 secretion have identified free fatty Actinomycin D receptor 4 (FFA4/GPR120) as a potential 7TM receptor involved

• br Introduction Fructose bisphosphatase FBPase EC catalyses

  2022-04-18

  

  Introduction Fructose 1,6-bisphosphatase (FBPase; EC 3.1.3.11) catalyses the irreversible reaction of hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate [1]. Genetic and kinetic studies so far have demonstrated that at least two distinct isoenzymes of FBPase e

• In skeletal as well as in the heart muscle the

  2022-04-18

  

  In skeletal as well as in the icrt muscle, the same FBPase isozyme is present (Gizak and Dzugaj, 2003). On the other hand, different isoforms of 6-fructo-2 kinase/fructose-2,6-bisphosphatase (FBPase-2/PFK-2) have been discovered in muscle fibres and cardiomyocytes (Okar et al., 2001, Marsin et al.,

• HBC To enhance the impact of GD as an immune

  2022-04-18

  

  To enhance the impact of GD2 as an immune target in this cancer, we investigated a novel strategy to upregulate expression on the cell surface of EwS cells by an epigenetic agent, based on the following rationale. Biosynthesis of GD2 and other gangliosides during organ development is driven by stage

• Based on the aforementioned findings variations

  2022-04-16

  

  Based on the aforementioned findings, variations of the imidazole heterocycle present in the endogenous ligand histamine (1) led to 2-(thiazol-2-yl)ethanamine (2-TEA, 2) and later to 2-(3-bromophenyl)histamine or 2-(3-(trifluoromethyl)phenyl)histamine (3) (Fig. 3). Interestingly, 2-TEA demonstrated

16308 records 490/1088 page Previous Next First page 上5页 486487488489490 下5页 Last page