• In this study in an effort to explore

  2024-10-23

  

  In this study, in an effort to explore the possible role of 5-HT6 receptors in mediating the memory-enhancing effects of YL-0919, we first assessed the memory-enhancing effects of YL-0919 in the Morris water maze, object recognition test and step-down passive avoidance task. In addition, we then inv

• Double immunofluorescence staining of Gas and Axl

  2024-10-23

  

  Double immunofluorescence staining of Gas6 and Axl with neuronal specific nuclear protein (NeuN), glial fibrillary acidic protein (GFAP), and ionized calcium-binding adaptor molecule 1 (Iba-1), demonstrated that Gas6 and Axl are expressed by neurons, astrocytes and microglia/macrophages (Fig. 2). In

• flag tag br Autophagy and cell death pathways

  2024-10-23

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic flag tag injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference in morpholo

• Among the most important Ca regulatory mechanisms are

  2024-10-23

  

  Among the most important Ca regulatory mechanisms are the Plasma Membrane Calcium ATPase (PMCA) and Sarcoplasmic Reticulum Calcium ATPase (SERCA). These pumps belong to the family of P-ATPases, which share the formation of an acid-stable phosphorylated intermediate as part of their reaction cycle. P

• br Colorectal carcinoma The growth rate of

  2024-10-23

  

  Colorectal carcinoma The growth rate of murine colon adenocarcinoma tumors decreased upon inhibition of 5-LOX, an enzyme that harbors counteracting properties to 15-LOX [28]. It is not clear whether 15-LOX was associated with this phenomenon, but its expression is induced in the colon carcinoma c

• To better illustrate the involved neuronal postganglionic

  2024-10-22

  

  To better illustrate the involved neuronal postganglionic pathways, central apelin-13 injection was performed in rats received peripheral preadministration of NOS inhibitor L-NAME, sympatholytic agent guanethidine and/or muscarinic receptor agonist bethanechol. Compared with the rats received vehicl

• Introduction Alzheimer s disease AD is a complex neurologica

  2024-10-22

  

  Introduction Alzheimer's disease (AD) is a complex neurological disorder characterized by a progressive dementia resulting from synapse failure (Selkoe, 2002, Tanzi, 2005). The amyloid hypothesis maintains that the pivotal event in AD is the production of amyloid-β (Aβ) peptides following the prote

• br Materials and methods br Results and discussion

  2024-10-22

  

  Materials and methods Results and discussion First, we examined whether hypothalamic Akt-mediated signaling pathways are regulated postprandially in chickens. Refeeding significantly (P lipid peroxide concentrations significantly increased in chicks after 1 h of refeeding (958 ± 245% of 24 h-

• br Introduction Our ability to see our

  2024-10-22

  

  Introduction Our ability to see our surrounding relies directly on the integrity of the anatomical structures composing our eyes. One of these key components is the cornea, consisting of the outer layer of the eye. Its transparency is crucial for light transmission to the retina and allows proper

• PKA signalling in the http

  2024-10-22

  

  PKA signalling in the nucleus was thought to be due to the translocation of the catalytic subunit upon activation from the CHIR-090 to the nucleus via diffusion [72]. However, a new understanding has emerged, as both the regulatory and catalytic subunits have been identified in the nucleus and funct

• In the olfactory bulb expression was especially prominent in

  2024-10-22

  

  In the olfactory bulb, expression was especially prominent in the mitral cell layer from embryonic stages to adult tissues (Figs. 1D–G). By E14–E16, Ack1 signal was remarkably intense in the proliferative ventricular zone (Fig. 1D). From E18 to adult, expression was also observed in glomerular and g

• Introduction br This paper is a commentary on the history

  2024-10-22

  

  Introduction This paper is a commentary on the history of language among the Aché. What was language for the Aché prior to contact with Paraguayan society? How has the Aché language come to be endangered? Why is language such an important issue today? In exploring these questions I come to a slig

• br Acknowledgments br Introduction Cancer is the leading

  2024-10-21

  

  Acknowledgments Introduction Cancer is the leading cause of mortality in the United States for those between the ages of 40–79 years, surpassing heart diseases by more than 100,000 deaths [1]. The cause of most cancer subtypes remains idiopathic and may arise out of ‘bad luck’ among otherwise

• Nowadays more than kinases have been

  2024-10-21

  

  Nowadays, more than 500 kinases have been identified of human genome [2]. Imatinib (Gleevec) was the first tyrosine kinase inhibitor approved by the US Food and Drug Administration (FDA) for the treatment of chronic myeloid leukemia [3], and kinases have become an attractive target for the developme

• The tumor suppressor function of LOX

  2024-10-21

  

  The tumor-suppressor function of 15-LOX-2 in normal prostate epithelial cells may be explained by the induction of replicative senescence [14,15]. Thus, 15-LOX-2 is overexpressed in age-dependent prostatic hyperplasia, but cell senescence may hinder progression to malignant transformation. Notwithst

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