• br Methods br Results br Discussion br Acknowledgements br

  2023-09-18

  

  Methods Results Discussion Acknowledgements This work was supported by the National Institutes of Health [Grant R21 NS081429], a Pilot Grant from the Vanderbilt Conte Center supported by the National Institutes of Health [Grant P50 M096972], and by the Department of Anesthesiology at V

• OSU-03012 australia Thus one possible target for CRPC treatm

  2023-09-18

  

  Thus one possible target for CRPC treatment is the enzyme 17,20-lyase, which plays a crucial role in androgen biosynthesis. This is because inhibition of 17,20-lyase would be expected to decrease serum androgen levels secreted not only by the testes but also by the adrenal glands.7, 8, 9 In recent

• br Autophagy inducers Macroautophagy is often

  2023-09-18

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of crizotinib and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensitivity of c

• br Funding This study was supported by Grant UM

  2023-09-18

  

  Funding This study was supported by Grant UM1-CA186690 (NCI-CTEP) and R01CA204173 (CJB). This project used the UPCI Cancer Pharmacokinetics and Pharmacodynamics Facility (CPPF) and was supported in part by award P30-CA47904 and R50CA211241. Introduction Despite the efficacy of platinum based

• Many coumarin derivatives can be found in

  2023-09-18

  

  Many coumarin derivatives can be found in nature. There are more than 1300 types of those purely derived from plants, and if synthetic products are included, their number is immeasurable. According to the earliest existing records extant, herbs containing Psoralen-type compounds, e.g., methoxsalen,

• The use of FTAI can

  2023-09-18

  

  The use of FTAI can overcome the negative impact of low estrus detection efficiency, but implies effective synchrony of luteal function as well as synchronous growth and ovulation of a viable Colistin Sulfate follicle. Pregnancy rates obtained with FTAI may be comparable or better than those obtain

• This progressive behaviour is summarized in Fig

  2023-09-18

  

  This progressive behaviour is summarized in Fig. 4, which depicts the variation in convexity of the obtained cut-off patterns for the series of six antioxidants. The form and degree of convexity of the obtained cut-off curves should in principle correlate with the AOs hydrophobicities, and therefor

• br Conclusion These studies broadly demonstrate

  2023-09-16

  

  Conclusion These studies broadly demonstrate that dopamine and endocannabinoid signaling in the NAc can have diverse effects on AMPAR-mediated synaptic function depending on previous psychostimulant experience. Here, we examined mechanisms underlying the depotentiation of AMPAR-mediated synaptic

• As one of emerging high throughout

  2023-09-16

  

  As one of emerging high-throughout methods, metabolomics detects metabolites which are ultimate response of biological systems to environmental changes [14]. Metabolomics uncovers metabolic alteration at the systems level. Comparison of global metabolic profiling reflects some unidentified biologica

• br The MIR The MIR

  2023-09-15

  

  The MIR The MIR is defined by the ability of a single rat mAb to muscle or electric organ AChRs, typically mAb 35, to block binding of half or more of autoantibodies in human MG or EAMG [44], [45], [46]. Antibodies to the MIR are pathologically significant because they exhibit all the major patho

• LO is a soluble kDa enzyme composed of

  2023-09-15

  

  5-LO is a soluble 78 kDa enzyme, composed of an α-helix-rich catalytic domain and a regulatory β-sheet-rich C2-like domain. Depending on the cell type, 5-LO may be located in the cytosol, in the nucleoplasm, or in both compartments (Werz, 2002). Upon cell stimulation by agents that elevate intracell

• Because serum ATX activity and plasma LPA are

  2023-09-15

  

  Because serum ATX activity and 2-APB receptor LPA are well correlated with liver fibrosis stage histologically, both of these parameters merit consideration as novel markers of fibrosis. However, serum ATX activity may be a more useful test from a clinical laboratory perspective. First, LPA can inc

• The original Aurora kinase was identified during a phenotypi

  2023-09-15

  

  The original Aurora kinase was identified during a phenotypic screen for defects in mitotic spindles in Drosophila mutants. Aurora mutants were so named because of the morphological defects at the mitotic spindle resembling the Aurora borealis, or the Northern light [4]. The structure of the Auroras

• CHK has been reported to be

  2023-09-15

  

  CHK1 has been reported to be the kinase responsible for H3.3S31 phosphorylation in human ALT cancer AACOCF3 . However, in our study, knockdown of CHK1 in HEK293F (Figs. S1c and S6) or HeLa S3 (data not shown) cells did not result in a significant decrease in H3.3S31ph, which is in agreement with an

• Furegrelate sodium salt mg Tumor suppressor ARF regulates th

  2023-09-15

  

  Tumor suppressor ARF regulates the activity of p53 by inhibiting the functions of Mdm2. ARF is induced by hyperproliferative signals emanating from oncogenic Ras, overexpressed c-myc, and from deregulated E2F . ARF prevents p53 degradation and leads to increased p53 function by sequestering Mdm2 to

16303 records 293/1087 page Previous Next First page 上5页 291292293294295 下5页 Last page