• br Materials and methods br Results

  2024-04-19

  

  Materials and methods Results To explore the potential role of autophagy in drug resistance, we firstly performed immunohistochemistry to compare the histone demethylase inhibitor of p62 in paired primary, metastatic, and recurrent tumor tissues from 26 ovarian cancer patients. The expression

• Elevated expression of Aurora A and B frequently detected in

  2024-04-19

  

  Elevated expression of Aurora-A and -B frequently detected in a wide variety of human cancers strongly indicate that high expression of these kinases play roles in the development of cancer associated phenotypes. While Aurora-A has been shown to function as an oncogene when over expressed in mammali

• These results show that quercetin can restore the enzyme act

  2024-04-19

  

  These results show that quercetin can restore the enzyme activity of the cholinergic system nonneural induced by demyelination. The AChE activity has been used as an indicator of human cell aging with lowered levels commonly associated with older human red blood ω-Agatoxin TK [51]. The enzymes AChE

• br Ataxia telangiectasia and Rad related as a

  2024-04-19

  

  Ataxia–telangiectasia and Rad3 related as a therapeutic target Several concerns revolving around functional inhibition of ATR have hindered the exploitation of ATR as therapeutic target in cancer therapy and delayed the development of specific ATR kinase inhibitors. It was anticipated that pharma

• Estrogen exerts its genomic action via estrogen nuclear rece

  2024-04-19

  

  Estrogen exerts its genomic action via Asunaprevir receptor nuclear receptor: ERα and ERβ. The distribution of ERα and/or ERβ positive neurons in CNS of different species has been mapped extensively by various methods [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], although there are s

• br Results Of the U S jurisdictions surveyed

  2024-04-19

  

  Results Of the 51 U.S. jurisdictions surveyed (Table 1), 33 reported that hyperargininemia is one of the conditions for which all newborns are required to be screened, with the earliest screening reported in Massachusetts in 1999. Of the 18 other jurisdictions, an additional 5 reported that hyper

• In addition to peroxyl radicals the

  2024-04-19

  

  In addition to peroxyl radicals, the most found radical forms in biological systems, some of assays took into account other free radicals such as superoxide anion, hydroxyl, hydrogen peroxide, singlet oxygen and peroxynitrite. ORAC procedure was also modified using different radical sources such as

• br Conclusions br Transparency document br Acknowledgements

  2024-04-18

  

  Conclusions Transparency document Acknowledgements This work was supported by a grant from the European Commission FP6 “Neuroprion” – Network of Excellence and Royal Veterinary College Bioveterinary science research project funding. We thank Professor Alun Williams (Cambridge University) fo

• br Materials and Methods br

  2024-04-18

  

  Materials and Methods Author Contributions Conflicts of Interest Acknowledgments We thank Francine Jodelka for technical assistance and Gopal Thinakaran for the CTM-1 antibody. This work was financially supported by RFUMS internal research funding and NIHS10 OD 010662. Introduction A

• br Experimental section br Introduction NMDA receptor

  2024-04-18

  

  Experimental section Introduction NMDA receptor-induced increases in AMPAR trafficking to the synaptic surface mediates changes in synaptic efficacy in a number of squalene epoxidase regions (Shi et al., 1999, Sun et al., 2005, Frenkel et al., 2006). While this process has been linked to the

• br Author contributions br Financial disclosures br

  2024-04-18

  

  Author contributions Financial disclosures Acknowledgements We thank Ms. Eva So for the editorial assistance. This work was supported by grants from the National Natural Science Foundation of China (No. 81622015, 81571042 and 81501143) and the National Basic Research Program of China (No. 2

• br The lipoxygenase pathway in vascular physiology and patho

  2024-04-18

  

  The 12/15-lipoxygenase pathway in vascular physiology and pathology The mammalian 12- and 15-LOXs have high substrate specificity oxidizing predominantly ω−6 (arachidonic and linoleic acids) but also the ω−3 (docosahexanoic) CJ-42794 synthesis [86], [87], [88]. Different LOXs oxidize fatty acids

• br Acetaldehyde One of the most common

  2024-04-18

  

  Acetaldehyde One of the most common environmental aldehydes is acetaldehyde (CH2CHO). Acetaldehyde, which is highly volatile, has been classified as a Group I human carcinogen by the International Agency for Research on Cancer [30]. Aldehydes can form DNA adducts, including ring-open forms of cro

• A key step in the ADAR reaction is the

  2024-04-18

  

  A key step in the ADAR reaction is the formation of the adenosine covalent hydrate with a tetrahedral center at C6. The nucleoside analog 8-azanebularine (box in Fig. 6), with its relatively high propensity to form a covalent hydrate, is useful as an adenosine replacement in ADAR2 substrates to trap

• The acetylcholinesterase AChE inhibitor tacrine THA

  2024-04-18

  

  The acetylcholinesterase (AChE) inhibitor, tacrine (THA), exerts neuroprotective effects in time- and does-dependent manners against glutamate neurotoxicity (Takada-Takatori et al., 2006a, 2006b) and amyloid-β protein toxicity in PC12, a pheochromocytoma line (Wang et al., 2002; Xiao et al., 2000).

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